Message file for your isometric is of name mess and may be you are trying to use more than one Isodraft Session. Another possibility the last user had not properly closed out and the file is still open for editing by the previous user. Close isodraft and delete the file.
And if you do not get the filepath with only 'mess' written in the option file then:
Right Click on the PDMS shortcut on the desktop!
In the properties there will be start in location defined.